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Short for Number only used once. All blocks within a blockchain feature an encrypted nonce, which is also known as being hashed. Blockchain miners use computers to solve the mathematical computations to determine this nonce, receiving a reward for uncovering the solution. Has an entirely different meaning in English slang… be careful where you use this word!!

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“Every transaction on the Ethereum blockchain has its own nonce. Praise be to @Vitalik.”

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